23 Pellets – Selective Androgen Receptor Modulator (SARM) for Research Applications
S23 is a potent, non-steroidal selective androgen receptor modulator (SARMs UK) that has garnered significant interest in scientific research due to its high binding affinity and tissue-selective anabolic activity. Developed as a potential male contraceptive, S23 exhibits a strong affinity for androgen receptors, promoting muscle growth and bone density while minimizing androgenic effects on reproductive organs.
Chemical Properties
- Chemical Name: (2S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- Molecular Formula: C18H13F3N2O3
- Molecular Weight: 416.31 g/mol
- CAS Number: 1010396-29-8
- IUPAC Name: (2S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
Important Documents
Mechanism of Action
S23 functions by selectively binding to androgen receptors (AR) in muscle and bone tissues, inducing anabolic effects while exhibiting minimal activity in androgen-sensitive tissues such as the prostate. This selective binding promotes muscle hypertrophy and increased bone mineral density, making S23 a subject of interest for conditions like muscle wasting and osteoporosis. Additionally, S23 has been investigated for its potential to suppress spermatogenesis, indicating its utility in male contraception research.
Pharmacokinetics
Studies have demonstrated that S23 possesses high oral bioavailability and a half-life conducive to once-daily dosing. Its pharmacokinetic profile ensures sustained plasma concentrations, facilitating consistent anabolic effects. Metabolic pathways involve hepatic processing, with primary excretion through renal pathways.
Research Applications
1. Male Contraception
S23 has been explored as a potential male contraceptive due to its ability to suppress spermatogenesis effectively. Animal studies have shown dose-dependent suppression of sperm production, with spontaneous recovery upon cessation of treatment, indicating reversible contraceptive potential.
2. Muscle Wasting Disorders
The anabolic properties of S23 make it a candidate for research into treatments for muscle wasting conditions. Its high binding affinity to androgen receptors in muscle tissue suggests potential efficacy in promoting muscle growth and preventing atrophy.
3. Osteoporosis
S23’s ability to enhance bone mineral density positions it as a subject of interest in osteoporosis research. By selectively targeting bone tissue, S23 may offer therapeutic benefits in increasing bone strength and reducing fracture risk.
Safety Profile
While S23 exhibits promising anabolic effects, its safety profile necessitates careful consideration. Animal studies have reported potential side effects, including suppression of spermatogenesis and alterations in hormone levels. The long-term effects and safety in humans remain undetermined, underscoring the need for further research.
Handling and Storage
- Form: S23 is typically supplied as a crystalline powder, formulated into pellets for research use.
- Solubility: Soluble in organic solvents such as ethanol and DMSO; limited solubility in aqueous solutions.
- Storage Conditions: Store at -20°C in a dry, light-protected environment to maintain stability and prevent degradation.
- Shelf Life: S23 remains stable for up to two years when stored under recommended conditions.
Handling Precautions
- Personal Protective Equipment (PPE): Utilize appropriate PPE, including gloves, lab coats, and eye protection, when handling S23 to prevent accidental exposure.
- Spill Response: In the event of a spill, contain and clean up immediately using appropriate absorbent materials, following institutional safety protocols.
- Disposal: Dispose of waste material in accordance with local regulatory guidelines and institutional policies.
Legality and Regulatory Status
S23 is classified as a research chemical and is not approved for human use by regulatory agencies such as the U.S. Food and Drug Administration (FDA). Its sale and use are restricted to qualified researchers for laboratory-based studies. Unauthorized marketing or application of S23 for therapeutic purposes is prohibited and may be subject to legal action.
International Regulations
- United States: Not approved for human use; available solely for research purposes.
- United Kingdom: Research Only.
- European Union: Regulations vary by country; generally restricted to research applications.
Compliance Requirements
- Documentation: Maintain detailed records of your acquisition, storage, handling, and disposal in accordance with institutional and governmental regulations.
- Ethical Considerations: Ensure all research involving S23 adheres to ethical guidelines and has received appropriate institutional review board (IRB) or ethics committee approval.
