Advanced Refinement Kit

SR-9009 SAFETY DATA SHEET
GW0742 SAFETY DATA SHEET
S-4 SAFETY DATA SHEET

The Advanced Refinement Kit is a three-compound combination formulated for preclinical investigation of metabolic and oxidative pathways relevant to body composition research. It pairs two non-androgenic metabolic modulators with a mild tissue-selective SARM, forming a research framework that prioritises mitochondrial efficiency, lipid metabolism, and lean tissue preservation over direct anabolic stimulation.

The mechanistic rationale draws on three independent receptor systems. SR-9009 engages REV-ERB nuclear receptors to influence circadian and oxidative gene expression, GW0742 activates PPARδ to upregulate fatty acid oxidation and mitochondrial biogenesis, and S-4 contributes mild AR agonism for lean tissue retention. The convergence of REV-ERB, PPARδ, and AR signalling provides researchers with a comprehensive model of metabolic recomposition without significant disruption of the hypothalamic-pituitary-gonadal axis.

Included in this kit:

• 1 × SR-9009 | 100 pellets, 10 mg active compound per pellet
• 1 × GW0742 | 100 pellets, 10 mg active compound per pellet
• 1 × S-4 | 100 pellets, 25 mg active compound per pellet

Total: 300 pellets / 4,500 mg active compound.

Compound roles in this bundle:

SR-9009 (Stenabolic) – REV-ERB agonist supplying the circadian and oxidative metabolism axis, with documented effects on mitochondrial biogenesis, glucose uptake, and lipid profile modulation.

GW0742 – selective PPARδ agonist contributing the fatty acid oxidation component, modulating gene expression involved in lipid metabolism, glucose homeostasis, and endurance-related parameters.

S-4 (Andarine) – partial AR agonist providing tissue-selective anabolic activity to preserve lean mass and contractile performance under metabolically demanding research conditions.

Combined research applications:

• Preclinical models of metabolic recomposition combining oxidative and anabolic pathways
• Studies of mitochondrial biogenesis and β-oxidation under multi-receptor stimulation
• Investigation of endurance and exercise capacity in murine models
• Research into adipose tissue accumulation under high-fat dietary challenge
• Comparative analysis of non-androgenic versus AR-mediated contributions to body composition outcomes

This kit is positioned as an advanced metabolic combination with negligible HPG-axis impact, making it suitable for research programmes that require investigation of body composition through predominantly non-androgenic mechanisms.

⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.