Classification  |
|
| Compound class | Synthetic organic |
| IUPAC Name |
| 3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide |
| Database Links |
|
| BindingDB Ligand | 50366239 |
| ChEMBL Ligand | CHEMBL1961797 |
| GtoPdb PubChem SID | 310264681 |
| PubChem CID | 57394021 |
| Search Google for chemical match using the InChIKey | PPUYOYQTTWJTIU-UHFFFAOYSA-N |
| Search Google for chemicals with the same backbone | PPUYOYQTTWJTIU |
| UniChem Compound Search for chemical match using the InChIKey | PPUYOYQTTWJTIU-UHFFFAOYSA-N |
| UniChem Connectivity Search for chemical match using the InChIKey | PPUYOYQTTWJTIU-UHFFFAOYSA-N |
SR9011 Guide
SR9011 is a lab-made compound that’s excited researchers for its potential effects on metabolism, endurance, and how our internal clocks tick (circadian rhythms). However, it’s still in the research phase and hasn’t been approved for medical use in humans yet. So far, it’s mostly been tested in animal studies, where it’s shown some promising benefits.
1. Chemical and Structural Details
- IUPAC Name: 1-(4-Chlorophenyl)-3-[3,5-dimethyl-4-(trifluoromethyl)phenyl]urea
- Molecular Formula: C₂₃H₃₁ClN₄O₃S
- Molecular Weight: 437.04 g/mol
Key Structural Highlights:
The structure includes a chlorophenyl ring and another phenyl ring that’s modified with a trifluoromethyl group. These parts are connected by a urea group, which helps SR9011 specifically target REV-ERBα and REV-ERBβ receptors.
2. How SR9011 Works
SR9011 is a strong activator (agonist) of the REV-ERB receptors, particularly REV-ERBα and REV-ERBβ. Here’s what these receptors are responsible for:
- Circadian Rhythms: They help control the body’s internal clock, which influences sleep patterns, hormone cycles, and overall metabolism.
- Metabolism: REV-ERBα is key in managing energy balance, fat metabolism, and how mitochondria (the cell’s powerhouses) work, especially in the liver and muscles.
By activating these receptors, SR9011 can:
- Boost energy use: It turns on genes that improve how cells burn fat and use glucose.
- Cut down fat production: It lowers the formation of new fat cells and can reduce triglycerides.
- Better sleep-wake cycles: It helps sync your internal clock, which can improve sleep quality and daytime alertness.
3. Promising Benefits Seen in Animal Studies
So far, SR9011 hasn’t been tested in humans, but in animal studies, it’s shown some interesting results:
- Better Exercise Endurance: Mice on SR9011 could run longer and had more stamina—suggesting their muscles were working more efficiently.
- Fat Loss Without Exercise: The compound sped up metabolism in rodents, leading to weight loss even without extra physical activity.
- Improved Blood Lipids: It helped lower cholesterol and triglyceride levels, which could benefit heart health.
- Anti-inflammatory Effects: There’s some evidence it may reduce inflammation by blocking certain inflammatory proteins.
Based on these findings, SR9011 might be useful in the future for conditions like:
- Obesity and metabolic issues
- Type 2 diabetes
- Cardiovascular problems
- Sleep disorders related to circadian rhythms
- Muscle loss conditions like sarcopenia
4. Safety Considerations and Limitations
- Not Approved for Human Use: SR9011 is still classified as a research chemical and hasn’t been cleared by the FDA for human use.
- Safety Profile: Animal studies haven’t shown major side effects at typical doses, but we don’t know its long-term safety in humans.
- Potential Risks: Because it’s so powerful in altering metabolic functions, it might come with risks like hormone imbalances, liver strain, or other unexpected effects if not used carefully.
- SR9011 is not a SARM, to view our range of SARM compounds, you can buy sarms UK here
5. SR9011 Structure Analysis
The molecular structure of SR9011 consists of three main parts:
- Aromatic Rings: The molecule contains two phenyl rings:
- One is substituted with a chlorine atom (chlorophenyl).
- The other ring is substituted with methyl groups at the 3rd and 5th positions and a trifluoromethyl group at the 4th position.
- Urea Linkage: The two aromatic rings are connected via a urea group (—NH—CO—NH—), which acts as a bridge. This functional group is crucial for binding interactions with its target receptors
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