MK-29 Pellets (Ostarine-O-Acetate)
MK-29, also known as Ostarine-O-Acetate, is a novel selective androgen receptor modulator (SARMs UK) designed for research applications. This compound is an acetylated derivative of Ostarine (MK-2866), engineered to enhance anabolic activity and improve pharmacokinetic properties.
Product Features and Specifications
- Chemical Formula: C19H14F3N3O3
- Molecular Weight: 389.33 g/mol
- Form: White to off-white pellets, ensuring controlled release and stability.
- Purity: ≥99% as determined by HPLC analysis.
- Solubility: Soluble in DMSO, ethanol, and other organic solvents.
- Storage Conditions: Store at -20°C in a dry, light-protected environment to maintain stability.
Applications
MK-29 Pellets are suitable for various research areas, including:
- Muscle Wasting Disorders: Investigating potential therapeutic effects on muscle preservation and growth.
- Osteoporosis Research: Studying the impact on bone density and strength.
- Metabolic Studies: Exploring effects on body composition, including fat reduction and lean muscle mass enhancement.
Research Insights
While specific studies on MK-29 are limited, research on its parent compound, Ostarine (MK-2866), provides valuable insights:
- Anabolic Effects: Ostarine has demonstrated significant anabolic activity in skeletal muscle, suggesting potential benefits in treating muscle wasting conditions.
- Bone Health: Studies indicate that Ostarine may positively influence bone density, making it a candidate for osteoporosis research.
- Metabolic Impact: Research suggests that Ostarine can improve body composition by increasing lean muscle mass and reducing fat mass.
The acetylation in MK-29 is hypothesized to enhance these effects, though further research is necessary to confirm its efficacy and safety.
Chemist’s view
MK-29, known chemically as Ostarine-O-Acetate, represents a significant advancement in the field of selective androgen receptor modulators (SARMs). It is an acetylated derivative of MK-2866 (Ostarine), designed to enhance pharmacokinetics and improve overall bioavailability. From a chemist’s perspective, MK-29 builds upon the molecular framework of its predecessor while aiming to address limitations in stability and metabolic degradation.
Structurally, MK-29 retains the trifluoromethylated aromatic core characteristic of MK-2866, essential for its high affinity and selectivity toward androgen receptors (AR). The addition of an acetate group introduces a protective functionalization, potentially shielding the molecule from premature enzymatic hydrolysis. This modification enhances systemic circulation and ensures prolonged activity in target tissues such as skeletal muscle and bone. The acetate moiety also contributes to the compound’s lipophilicity, promoting better membrane permeability and absorption kinetics.
The mechanism of action of MK-29 centers on its selective binding to ARs in anabolic tissues. Unlike traditional anabolic agents, MK-29 avoids significant interaction with non-target receptors in the prostate or other androgen-sensitive tissues, minimizing undesirable side effects. This specificity is a result of the finely tuned electronic and steric properties of the molecule’s substituents, enabling precise receptor activation without the broader androgenic activity seen with testosterone or anabolic steroids.
In the laboratory, MK-29 presents exciting opportunities for exploring therapeutic applications in muscle-wasting disorders, osteoporosis, and age-related sarcopenia. Its chemical stability, compared to other SARMs, allows for extended study durations, providing reliable and reproducible data in preclinical research. Solubility in polar organic solvents such as DMSO and ethanol facilitates formulation for in vitro assays and in vivo studies.
Handling and Safety
- Intended Use: For research purposes only. Not for human or veterinary use.
- Safety Precautions: Handle with appropriate laboratory safety protocols. Use personal protective equipment to prevent accidental exposure.
- Documentation: Material Safety Data Sheet (MSDS) available upon request for detailed safety and handling guidelines.
Packaging Options
- Available in 5 mg, 10 mg, and 50 mg pellet formulations.
- Custom packaging and bulk quantities are available upon request to meet specific research needs.
Technical Support
Our team offers comprehensive technical assistance for the application and handling of MK-29 Pellets. Contact us for protocol optimization, analytical support, and troubleshooting to ensure successful research outcomes.
