Description
SAFETY DATA SHEET
MK-677 HPLC BA34001
MK-677 COA BA34001
Ibutamoren, also known as MK-677, is an orally active, long-acting growth hormone secretagogue that mimics the action of ghrelin by binding to the ghrelin receptor (GHS-R1a) in the brain. This results in a sustained, dose-dependent increase in circulating growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels without significantly affecting cortisol or prolactin secretion. Unlike recombinant GH administration, MK-677 stimulates natural pulsatile release of growth hormone, which may preserve physiological feedback mechanisms and receptor sensitivity.
In clinical and experimental settings, MK-677 has demonstrated the ability to:
- Facilitate increases in fat-free mass and enhances nitrogen balance in preclinical models
- Modulate IGF-1-mediated signaling pathways implicated in skeletal muscle regeneration and tissue repair
- Demonstrate potential to influence bone mineral density parameters, particularly in age-related research contexts
- Affect sleep architecture and REM phase duration, likely through central ghrelin receptor (GHS-R1a) activation
- Alter gene expression and signaling cascades associated with dermal, follicular, and extracellular matrix dynamics in regenerative biology models
Ibutamoren’s oral bioavailability, extended half-life, and minimal suppression of endogenous hormone production make it an attractive candidate for long-term research into GH-related therapies, sarcopenia, and age-associated decline in anabolic hormones.
CAS Number: 159752-10-0
Molecular formula: C27H36N4O5S
Molar mass: 528.7 g/mol
Purity: ≥99% (see HPLC and COA documentation)
Concentration: 10 mg
Half-life: ~24 hours
Storage: 2 years at 20°C
⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.
What Is MK-677 (Ibutamoren)?
A non-peptide growth hormone secretagogue used in investigational studies on GH axis modulation, aging, and muscle wasting.
MK-677, not to be confused with MK-2866 (Ostarine) also known by its research code Ibutamoren mesylate, is a selective, orally active growth hormone secretagogue (GHS). It is not a SARM (Selective Androgen Receptor Modulator) but is frequently grouped with them due to its presence in performance-enhancement and metabolic studies.
🔬 Mechanism of Action
MK-677 functions as a ghrelin receptor agonist — specifically targeting the GHS-R1a (Growth Hormone Secretagogue Receptor 1a) located in the hypothalamus and pituitary.
Once bound:
- It mimics endogenous ghrelin, stimulating pulsatile GH release
- This cascade leads to elevated IGF-1 levels, a key mediator of tissue growth and recovery
- Unlike traditional GH therapies, MK-677 does not suppress endogenous hormone production
“In contrast to exogenous GH, MK-677 stimulates physiological GH release, preserving hypothalamic–pituitary signaling.”
— Murphy et al., J Clin Endocrinol Metab, 1998
📊 Key Research Findings
| Study Domain | Findings |
|---|---|
| GH/IGF-1 axis | Increases GH and IGF-1 levels dose-dependently (e.g., 1–3 mg/kg) |
| Body composition | Promotes lean body mass retention and slight fat loss in clinical studies |
| Muscle preservation | Shown to mitigate age-related sarcopenia and improve muscle strength |
| Bone density | May enhance bone turnover markers via IGF-1 activity |
| Sleep studies | Improves REM sleep duration and sleep quality metrics |
⚠️ Important Notes for Research Use
- Not approved for human use outside of clinical trials
- Typically studied in double-blind, placebo-controlled settings
- Pharmacokinetics show a long half-life (~24 hours) and oral bioavailability
- Some studies report transient increases in blood glucose and appetite
“MK-677 is a promising compound for long-term GH/IGF-1 modulation, but requires careful metabolic monitoring in trial models.”
— Smith et al., Growth Horm IGF Res, 2000
🧪 Typical Research Use Parameters
| Form | Oral suspension / powder (research-grade) |
|---|---|
| Dose Range (animal/lab) | 5–25 mg/day depending on model size and metabolism |
| Study Duration | 2–12 weeks in preclinical and human studies |
| Detection Method | LC-MS/MS for plasma analysis; GH and IGF-1 serum assays |
Summary & Further reading
Read our articles:
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MML Support (store manager) –
Hi Albert,
Thanks for your feedback — we appreciate you taking the time to leave a review.
If there’s anything we can do to make your experience a 5-star one next time, feel free to let us know!
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