Max Muscle Labs Archem MK-677 Ibutamoren bottle, chemical structure shown, 10 mg dosage, labeled for research use only.
Chromatogram showing peak of MK677 at retention time 11.950 min, with integration table detailing peak areas and heights.
Certificate of analysis for MK-677, highlights purity, concentration, identity and conformity to specifications.

MK-677 (Ibutamoren) | 100 x 10mg

(34 customer reviews)

£49.90

  • Always ≥ 99% purity
  • Manufactured and sealed in a sterile environment
  • Up to 70% more value in each bottle
  • Each batch is independently double-tested

SAFETY DATA SHEET

Ibutamoren, also known as MK-677, is an orally active, long-acting growth hormone secretagogue that mimics the action of ghrelin by binding to the ghrelin receptor (GHS-R1a) in the brain. This results in a sustained, dose-dependent increase in circulating growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels without significantly affecting cortisol or prolactin secretion. Unlike recombinant GH administration, MK-677 stimulates natural pulsatile release of growth hormone, which may preserve physiological feedback mechanisms and receptor sensitivity.

In clinical and experimental settings, MK-677 has demonstrated the ability to:

  • Facilitate increases in fat-free mass and enhances nitrogen balance in preclinical models
  • Modulate IGF-1-mediated signaling pathways implicated in skeletal muscle regeneration and tissue repair
  • Demonstrate potential to influence bone mineral density parameters, particularly in age-related research contexts
  • Affect sleep architecture and REM phase duration, likely through central ghrelin receptor (GHS-R1a) activation
  • Alter gene expression and signaling cascades associated with dermal, follicular, and extracellular matrix dynamics in regenerative biology models

Ibutamoren’s oral bioavailability, extended half-life, and minimal suppression of endogenous hormone production make it an attractive candidate for long-term research into GH-related therapies, sarcopenia, and age-associated decline in anabolic hormones.

⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.

Frequently Asked Questions about MK-677

Ibutamoren (MK-677) / Frequently Asked Questions

What Is MK-677 (Ibutamoren)?

MK-677 is a non-peptide growth hormone secretagogue used in investigational studies on GH axis modulation, aging, and muscle wasting.

MK-677, not to be confused with MK-2866 (Ostarine) also known by its research code Ibutamoren mesylate, is a selective, orally active growth hormone secretagogue (GHS). It is not a SARM (Selective Androgen Receptor Modulator) but is frequently grouped with them due to its presence in performance-enhancement and metabolic studies.

Core learning: What you need to know about MK677

Mechanism of Action

MK-677 functions as a ghrelin receptor agonist — specifically targeting the GHS-R1a (Growth Hormone Secretagogue Receptor 1a) located in the hypothalamus and pituitary.

Once bound:

  • It mimics endogenous ghrelin, stimulating pulsatile GH release
  • This cascade leads to elevated IGF-1 levels, a key mediator of tissue growth and recovery
  • Unlike traditional GH therapies, MK-677 does not suppress endogenous hormone production

“In contrast to exogenous GH, MK-677 stimulates physiological GH release, preserving hypothalamic–pituitary signaling.”
– Murphy et al., J Clin Endocrinol Metab, 1998

Key Research Findings

Study DomainFindings
GH/IGF-1 axisIncreases GH and IGF-1 levels dose-dependently (e.g., 1-3 mg/kg)
Body compositionPromotes lean body mass retention and slight fat loss in clinical studies
Muscle preservationShown to mitigate age-related sarcopenia and improve muscle strength
Bone densityMay enhance bone turnover markers via IGF-1 activity
Sleep studiesImproves REM sleep duration and sleep quality metrics

Important Notes for Research Use

  • Not approved for human use outside of clinical trials
  • Typically studied in double-blind, placebo-controlled settings
  • Pharmacokinetics show a long half-life (~24 hours) and oral bioavailability
  • Some studies report transient increases in blood glucose and appetite

“MK-677 is a promising compound for long-term GH/IGF-1 modulation, but requires careful metabolic monitoring in trial models.”
— Smith et al., Growth Horm IGF Res, 2000

Typical Research Use Parameters

FormOral suspension / powder (research-grade)
Dose Range (animal/lab)5–25 mg/day depending on model size and metabolism
Study Duration2–12 weeks in preclinical and human studies
Detection MethodLC-MS/MS for plasma analysis; GH and IGF-1 serum assays

Summary & Further reading

Read our articles:

Delivery - UK

Next working day

Delivery - Worldwide

5-7 working days + customs processing time (varies)

Stock levels

Low

CAS Number

159752-10-0

Molecular formula

C27H36N4O5S

Molar mass

528.7 g/mol

Purity

≥99% (see HPLC and COA documentation)

Concentration

10 mg

Half-life

~24 hours

Storage

2 years at 20°C

  1. Rob –

    Great product. I recommend it!

  2. Tristan –

    packaging and shipping was great. excellent research results.

  3. Sam –

    strong

  4. Liam –

    Seems reliable

  5. John –

    so far so good will come back for more

  6. Tom –

    This product is legit. Great experience.

  7. Darren –

    good quality sarms

  8. William –

    great ,so good, thans so much for everything

  9. Harry –

    Works

  10. Nathan –

    Quality products delivered quickly.

  11. Ivan –

    Awesome. It arrived in Czechia in 5 days. I had no problems whatsoever 10/10

  12. Gary –

    Works well

  13. Chris –

    After being unsure and doing a lot of reading, I found this website, and I’m very happy that I did. I’m glad to know there is somewhere I can go to feel confident about this kind of product. Tnx for communicating with me through the process.

  14. Richard –

    Best value (price and quality) on the internet

  15. david –

    I’m very impressed with this material. Thank you!

  16. collin –

    legit 100%

  17. Jim –

    Valid

  18. Shawn –

    Kinda surprised me to be honest quality is on point

  19. Philip –

    Good

  20. David –

    Accurate description. Conforms to chemical specifications.

  21. Bill –

    Awesome, worked just as I expected

  22. Scott –

    It’s definitely one of the best out there. This has to be the purest as I haven’t come across these effects in research from other companies yet.

  23. Albert –

    ok

  24. Thomas –

    I actually like the result

  25. Alex –

    quick delivery

  26. Nick –

    I purchased MK677 about two weeks ago. It arrived quickly. The quality is excellent.

  27. andrew –

    Getting great results

  28. Dennis –

    Fast delivery Priced reasonable

  29. james –

    great

  30. Cory –

    Extremely fast service thank you

  31. Eric –

    Good stuff. Definitely will order from them again.

  32. Kenneth –

    I checked the lab reports and they seem legit

  33. Robert –

    Really high quality

  34. Jordan –

    Im impressed with how good and effective MMS/Archem RAD-140 and MK-677 are. They work well and you can rely on them, so its a good choice for research

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