LGD-3303 / 100 x 5mg

Description

LGD-3303 is a nonsteroidal Selective Androgen Receptor Modulator (SARM) under investigation in preclinical research for its tissue-selective anabolic properties. In comparative studies, LGD-3303 has demonstrated potent androgen receptor agonism in skeletal muscle and partial agonist activity in other androgen-responsive tissues, contributing to its favorable selectivity profile.

This compound was developed to address certain limitations observed in earlier generation SARMs, such as LGD-4033, with particular improvements in oral bioavailability and bone-anabolic activity. In vivo studies have shown that LGD-3303 supports the preservation of lean body mass and enhances skeletal parameters, including bone mineral density and biomechanical strength, with minimal androgenic stimulation in non-target tissues.

In preclinical studies, LGD-3303 has demonstrated the ability to:

• Induce anabolic signaling in skeletal muscle tissue, contributing to the maintenance of lean body mass under androgen-deprived or catabolic conditions
• Enhance bone mineral density (BMD) and improve biomechanical properties of skeletal structures in ovariectomized and castrated animal models, supporting its utility in investigating bone-loss mechanisms
• Display a high degree of tissue selectivity, with limited androgenic activity in non-target organs such as the prostate, even at concentrations that elicit measurable anabolic responses
• Alter metabolic parameters in vivo, with preliminary indications of an effect on glucose metabolism and nutrient partitioning in animal studies
• Exhibit oral bioavailability and favorable pharmacokinetic characteristics, including high binding affinity for the androgen receptor (AR)

Ongoing research involving LGD-3303 includes its use in experimental models of musculoskeletal degeneration, androgen deficiency, and age-associated sarcopenia and osteopenia. Its pharmacological profile makes it a candidate of interest for investigating selective androgen receptor modulation mechanisms without the off-target effects typically associated with classical anabolic agents.

CAS Number: 917891-35-1
Molecular formula: C16H14ClF3N2O
Purity: ≥99% (see HPLC and COA documentation)
Concentration: 5 mg
Molar mass: 342.75 g/mol
Half-life: Estimated ~6–12 hours

⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.