SR9009 (Stenabolic) / 100 x 5mg

Description

SR-9009 (Stenabolic) is a synthetic agonist of the REV-ERBα/β nuclear receptors. Although not classified as a selective androgen receptor modulator (SARM), it is frequently included in research investigating metabolic and endurance-related pathways due to its significant effects on cellular energy regulation. SR-9009 engages REV-ERB receptors, which are integral to the regulation of circadian rhythms, mitochondrial biogenesis, lipid metabolism, and inflammatory responses.

Activation of REV-ERBα by SR-9009 modulates the transcriptional activity of genes implicated in energy expenditure, glucose and lipid homeostasis, and mitochondrial oxidative capacity. These mechanisms have made SR-9009 a molecule of interest in preclinical models of metabolic disorders, including obesity, dyslipidemia, and reduced exercise capacity.

In preclinical studies using murine models, SR-9009 has been shown to:

• Enhance endurance and exercise capacity via upregulation of mitochondrial biogenesis and oxidative metabolism in skeletal muscle
• Promote glucose uptake and reduce adiposity independent of caloric restriction or physical activity
• Suppress de novo lipogenesis and cholesterol biosynthesis, leading to improved lipid profiles
• Reduce systemic inflammation through modulation of cytokine expression
• Influence circadian gene expression, suggesting potential applications in models of sleep disturbance or metabolic dysregulation

Notably, SR-9009 does not interact with androgen receptors and lacks the hormonal activity associated with androgen modulators. It does not induce testosterone suppression, nor does it necessitate post-administration hormonal intervention. However, its limited oral bioavailability and rapid systemic clearance have led to continued research into structurally related analogs and optimized delivery modalities to enhance its pharmacokinetic profile.

CAS Number: 1379686-30-2
Molecular formula: C20H24ClN3O4S
Purity: ≥99% (see HPLC and COA documentation)
Concentration: 5 mg
Molar mass: 437.94 g/mol
Half-life: ~2–4 hours

⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.