How Androgens & SARMS Work within the Human Body
Androgens are natural or synthetic hormones. The hormones determine the development of male sexual characteristics. Androgens bind to nuclear receptors known as androgen receptors and regulate the growth and maintenance of sex organs in male vertebrates. The hormones also determine the secondary sexual characteristics in men, especially during puberty. The hormones are synthesized in male testes, female ovaries and adrenal glands. While the term androgen is derived from the Greek word andr which means man, the hormone is not only found in males but also females. The quantum of hormones found in females is much lower than their secretions in males.
The most important androgen in men is testosterone. The primary androgen is converted to dihydrotestosterone and androstenedione, both of which are necessary for optimum male development. However, the conversion should be optimally regulated to prevent an excess of dihydrotestosterone through the process of aromatization. Androgens in females determine sexual arousal and libido. Androgens are natural hormones but synthetic versions of the same are used in medicines and in various types of medical treatments. Androgen replacement therapy may use SARMs or selective androgen receptor modulators.
Functions of Androgens in the Human Body
There are a few types of androgens. The important ones are known as adrenal androgens. These work like weak steroids. This group includes dehydroepiandrosterone, androstenedione and dehydroepiandrosterone sulfate. Dehydroepiandrosterone is secreted by the adrenal cortex. Androstenedione is secreted in adrenal cortex and testes in men. It is secreted in ovaries in females. The most important androgen is the primary sex hormone in men called testosterone. Other androgens are androstenediol and androsterone.
Androgens play a vital role in prenatal development in males. It regulates testes formation. Androgens determine whether the gonads would become testes or ovaries. The gonads are capable of either during the mammalian development, usually around the fourth week of pregnancy. SARMs UK are also indicated for use in androgen deficient patients.
Optimum production of androgens regulates the development of testes as the epithelial cells become Sertoli cells. The Sertoli cells support formation of sperm cells. Androgens serve as paracrine hormones that enable Sertoli cells to determine masculinization. This is crucial in the development of the penis and scrotum in male fetus. Androgens lead to the development of Wolffian ducts into the vas deferens, seminal vesicles and epididymis. In effect, androgens determine if a fetus will develop as a male or a female.
SARMS and male development
Androgens play an extremely important role in pubertal development of males. Levels of androgens increase in males during puberty. The levels of androgens also increase in females during puberty but not to the same extent. Androgens influence the development of secondary male sexual characteristics, after already having determined the primary ones during prenatal phases. Androgens influence fertility and behavioral changes that are classified as masculine.
Androgens determine libido and hence sex drive. The hormones also determine growth of hair, deepening of voice, the development of Adam’s apple, increase in muscle mass, broadening of shoulders and growth of the penis. All male characteristics that develop during puberty are regulated by androgens. Other hormones also play a part but the maculinization is mostly controlled, triggered and supported by androgens. Ostarine UK is considered for research into thisa
Men have less body fat percentage than women. This is due to many reasons and androgen is one of the main factors. Fat deposition is inhibited by optimum secretion of androgen hormones. Androgens play an active role in the growth and development of muscle mass. Men have better formed skeletal muscles and have more mass than women. This is primarily due to the role of androgens in supporting the enlargement of the cells in the skeletal muscles. Men with higher levels of androgens are likely to have stronger and larger skeletal muscles.
Androgens also influence cognitive functions to an extent. The precise levels of androgens at different stages will influence the functioning of neurons. A few neurons are actually sensitive to the hormones. Androgens can partly influence behavior such as aggression. While the hormones can change the brain structure in primates, rats and mice, such an effect is not observed in humans.
Androgen is one of the most important hormones in males. It is also an important hormone in females but since feminine sexual characteristics are mostly influenced by estrogens and the levels of androgens are much lower in women, the significance and also the function is limited.