An overview of the Clinical Safety of SARMS UK
“Selective androgen receptor modulators” or SARMS are a category of synthetic drugs that claim to be an elite upgrade of the infamous anabolic steroids. Their mode of administration is generally oral, although some of the drugs might be in injectable and highly concentrated form too which results in hurtling down the levels of blood testosterone. In a nutshell, they are a kind of androgen receptor ligands, but are far more selective than the conventional steroidal drug used currently. Although SARMS are used in treating medical conditions like Alzheimer disease and cancer, they are primarily known as performance enhancing drugs in the athletic market.
Setting aside all the sci-fi jargons, it is a fancy and easy way of building up muscles in the body without causing the age old ball shrinking effect and without taking a toll on your liver or your appearance (which is greatly affected by steroidal supplements due to unruly hair growth
Although rats have been the prime subjects for trial and testing of SARMs, multiple human trials have been recorded for SARMS drugs such as MK- 2866, also known as Ostarine which remains as the best studied and clinically tested SARM till date. It was noted in the clinical trials that Ostarine demonstrated no significant side effects and proved to be very effective in building muscles. An overview of the clinical safety of SARMS show that elderly women and men administering modest doses of MK-2866 showed a muscle gain of a pound every month without being involved in any type of muscle build up training or diet. Although there are no side effects reported, there might be testosterone suppression for short term if high doses of Ostarine are taken.
LGD- 4033 has also been studied better than other drugs and has been through multiple human trials. Healthy men taking LGD-4033 doses for 21 days showed increase in lean body mass while the only side effect reported in this case was testosterone suppression.
Cardarine (GW5O1516) doesn’t seem to have any human trials that can provide an overview of the clinical safety of SARMS but it shows promising results on rodents. Cardarine combined with exercise in rodents increased mitochondrial growth in muscle cells by 50% which meant that the same muscle could produce more power without any need of increasing power or mass.
A lot of hullabaloo has been created around SARMS drug & SARMS drug therapy since the last ten years or so but little do people know that SARMS had been around since ages and they were used for treating some complex medical conditions like cancer, osteoporosis, hypogonadism, curbing bone wasting etc. even back in 1940s, the only difference being that the category of SARMS that were popularly used back until mid- 90s was steroidal SARMS. Unfortunately, steroidal SARMS incur a number of side effects. This includes conditions like gynecomastia which is caused by estrogen conversion and is marked by development of puffy and sensitive nipples and decreased libido. Steroidal SARMS also lead to damage and degeneration of liver and kidneys which is attributed to its property of methylation.
Non Steroidal and Steroidal SARMS
As discussed above, it is evident that steroidal SARMS posed many dangers and side effects in general. So the scientists went ahead and created a protein based model of SARMs drug that rendered the much touted nonsteroidal SARMs drug their attribute of almost nugatory side effects. The mechanism is pretty much typical where both the effect and side effects depend upon the anabolic to androgenic ratio which remains 1:1 in steroids based drugs and is hiked upto 3:1 where adrogenic ratio is significantly reduced. All the troubles that are caused due to the steroidal drugs are because of the androgenic ratio which is considerably lowered in Nonsteroidal or NSARMs.
Speaking in layman terms, both the steroidal and nonsteroidal type SARMs work on the basis of lock and key modal where all the cells of our body have a lock in them in the form of receptors which can only be unlocked by the “key” present in the drugs. The problem is lies in the fact that the steroidal drugs have an anabolic to androgenic ratio of 1:1, i.e, they typically act as a “Master Key” to every type of cell and start promoting protein growth and synthesis everywhere. That means it is highly likely for the steroidal SARMs and other steroidal supplements to trigger enlargement of clitoris when they are being administered for the purpose of enlargement of muscles.
Now this is the interesting part- the reason why steroidal drugs are so catastrophic was taken as the starting point of the development of non- steroidal drugs. Their anabolic to adrogenic ratio was improved to an activity of 3:1 to the minimum and they now boast up to 90:1 anabolic to androgenic activity ratio in some of the drugs under NSARMs. So basically it means that the key present in the non – steroidal type SARMs is very specific and only binds to the part of DNA that is responsible for preventing muscle wastage and bone wastage. Needless to say, this is the reason why non – steroidal SARMs are so famous for having no side effects and high response rate
Effects and side effects of SARMS UK
SARMs are believed to have a number of benefits tagged to it. First off, it links with the very same receptors that steroidal drugs like Dianbol target, only deducting the bad side effects and drawbacks of those steroids and prohormones and thus help in reducing body fat while increasing the muscle mass. Additionally, SARMs are non- toxic so they do not cause any damage to the liver or kidneys and their ligand structure also leads to avoiding bone loss. Since the drug doesn’t goes about unlocking every single cell of the body, it typically reduces the threat of prostrate issues arising in men due to drug administration. It’s characteristic feature is no estrogen conversion while having testosterone like effect on the cells as the same time.